Certain aminosterol compounds and pharmaceutical compositions in

Details Certain aminosterol compounds and pharmaceutical compositions in Certain aminosterol compounds and pharmaceutical compositions in

1995-06-07

1998-12-08

Prior, Kimberly J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

C07J 4100

Patent

active

058471723

ABSTRACT:
Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.

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