Certain aminomethyl phenylimidazole derivatives; and 4-aryl subs

Details Certain aminomethyl phenylimidazole derivatives; and 4-aryl subs Certain aminomethyl phenylimidazole derivatives; and 4-aryl subs

1994-09-27

1997-05-27

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544295, 544364, 544370, 546193, 546194, 546210, 5483355, 5483401, 5483431, 5483435, C07D40306, C07D40304, C07D40106, C07D40104, C07D23364, A61K 31415

Patent

active

056333765

ABSTRACT:
This invention encompasses compounds of the formulas: ##STR1## where R.sub.1 R.sub.3, R.sub.4, R.sub.6, X, Y, and Z are T are variables; and
M is ##STR2## where R.sub.2 is a variable; or R.sub.1 and R.sub.2 together may represent --(CH.sub.2).sub.n1 where n.sub.1 is 1, 2, or 3.
These compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism. Furthermore compounds of this invention may be useful in treating the extraparamidyl side effects associated with the use of conventional neuroleptic agents.

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