Certain amido- and amino- substituted benzylamine derivatives; a

Details Certain amido- and amino- substituted benzylamine derivatives; a Certain amido- and amino- substituted benzylamine derivatives; a

1997-07-18

2000-10-17

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514248, 514249, 51425301, 51425305, 51425306, 51425401, 51425406, 51425503, 544121, 544235, 544353, 544354, 544357, 544360, 544364, 544365, 544363, 544367, 544368, 544370, 544371, 544379, 544393, A61K 315355, A61K 31496, C07D295155, C07D48704

Patent

active

061332658

ABSTRACT:
Amido, amino and sulfonamide substituted benzylamine derivatives useful in treating eating disorders have the formula ##STR1## where X.sub.1, X.sub.2, and X.sub.3, independently represent substituents of formula ##STR2## D=H, lower straight or branched chain alkyl having 1-6 carbon atoms, a methylene unit incorporated into a ring connected with G as in the cases of pyrrolidine, pyrrolidone, piperidine, and piperidone;
E=O or H.sub.2 ;
O=0 or 1;
G=straight or branched chain lower alkyl having 1-6 carbon atoms, aryl, aryl substituted with halogen, straight or branched chain lower alkyl having 1-6 carbon atoms, heteroaryl--selected from the group consisting of 2-, 3-, or 4-pyridyl, 2-pyrazyl, 2-, or 3-thienyl, 2-pyrazinyl, 2-, 3-, or 4-quinolyl, 1-, 3-, or 4-isoquinolyl, 2-quinoxalyl, 3-, or 4-cinnolyl, said heteroaryl substituted with halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, straight or branched chain lower alkoxy having 1-6 carbon atoms;
and A, T and R.sub.1 -R.sub.4 are hydrogen or organic substituents.

REFERENCES:
patent: 5900415 (1999-05-01), Peterson et al.
patent: 5962455 (1999-10-01), Blum et al.
patent: 5985873 (1999-11-01), Blum et al.
Grundemar et al., TiPS, 15, p 153-159 (1994).
Gehlert et al, Exp. Opin. Invest. Drugs 6, p 1827-1838 (1997).

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