Certain amide derivatives of 2-guanidino-thiazoles and compositi

Details Certain amide derivatives of 2-guanidino-thiazoles and compositi Certain amide derivatives of 2-guanidino-thiazoles and compositi

1983-04-29

1985-02-26

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546280, 548195, 544336, 514370, C07D41112, C07D26328, A01N 31455, A01N 3142

Patent

active

045017476

ABSTRACT:
Amides acting as histamine H.sub.2 receptors antagonists, of formula ##STR1## wherein X represents a N.fwdarw.O or C-NH-A-B group in which A is CO or SO.sub.2 and B is alkyl, phenyl, pyridyl, pyridyl 1-oxide, pyrazinyl or thienyl; their salts; process for their preparation by reacting 2-(2-guanidinothiazol-4-ylmethylthio)ethylamine with a derivative of formula ##STR2## and optional salification; and pharmaceutical compositions containing same.

REFERENCES:
patent: 3743647 (1973-07-01), Naito et al.

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