Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent
Patent
1977-04-05
1978-04-04
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen in the nitrogen containing substituent
544 27, 424246, 260250AC, 260514J, C07D50120, A61K 31545
Patent
active
040829120
ABSTRACT:
Certain 7-acylamido-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on- 6-ylthiomethyl)-3-cephem-4-carboxylic acids and their salts and easily hydrolyzed esters of the 4-carboxyl group were synthesized and found to be potent antibacterial agents which exhibited good aqueous solubility. A preferred embodiment was 7-[o-(methylaminomethyl)phenylacetamido]-3-(2-carboxyalkyl-2,3-dihydro-s-t riazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acid.
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Hoshi Hideaki
Iimura Seiji
Kamachi Hajime
Naito Takayuki
Oka Masahisa
Berch Mark L.
Bristol-Myers Company
Daus Donald G.
Taylor, Jr. Herbert W.
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