Certain 5,6-dihydro-prostacyclin analogs

Details Certain 5,6-dihydro-prostacyclin analogs Certain 5,6-dihydro-prostacyclin analogs

1977-12-05

1978-11-14

Jiles, Henry R.

Harness for working animal

542420, 542422, 542426, 542429, 260308D, 26034622, 26034673, C07D30793

Patent

active

041257120

ABSTRACT:
Processes for preparing 5,6-dihydro-prostacyclin analogs, which are 9-deoxy-6,9-cyclic ethers of prostaglandin F.sub.1.alpha. -type compounds, illustrated for example, by a compound of the formula ##STR1## wherein .about. indicates alpha or beta configuration; including the products and intermediates produced therein, said products having pharmacological utility.
There are also provided mercury derivatives of these 5,6-dihydro-prostacyclins, illustrated, for example, by a compound of the formula ##STR2## wherein G is nitrato, iodo, chloro, bromo, acetato, trifluoroacetato, or benzoato, and wherein .about. indicates alpha or beta configuration, said products having pharmacological activity, and useful as intermediates in preparing the above compounds.

REFERENCES:
johnson, et al., J. Am. Chem. Soc. 99, 4182, (1977).

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