Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1975-07-30
1978-04-18
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
260279R, 260283CN, 260283SY, 260287T, 260287CF, 260288R, 260288CF, 260289H, 2602948C, 2602949, 260295K, 260295F, 424257, 424263, C07D21548, A61K 3147, A61K 3144
Patent
active
040852156
ABSTRACT:
The invention relates to novel pyridine derivatives which have a fused 5,6, or 7-membered saturated hydrocarbon ring adjacent to the nitrogen of the pyridine ring, and a group X situated on said hydrocarbon ring and separated by one carbon atom from the pyridine nitrogen atom, said group X is cyano, CONHR.sup.3, CSNHR.sup.3 or CO.sub.2 R.sup.5 wherein R.sup.3 is selected from hydrogen, lower alkyl and lower aralkyl radicals and R.sup.5 is selected from hydrogen, lower alkyl and lower aralkyl radicals which may be substituted by alkyl, alkoxy, halogen, nitro or trifluoromethyl; other substituents may be present. Compounds wherein X is CSNHR.sup.3 are anti-ulcer agents and the other compounds are intermediates therefor.
REFERENCES:
patent: 3963722 (1976-06-01), Curran
patent: 3991060 (1976-11-01), Curran
patent: 4000142 (1976-12-01), Curran et al.
patent: 4009169 (1977-02-01), Curran et al.
Hagelloch et al.; Chem. Abs. vol. 46, col. 404.sup.7 i (1951).
Cook et al., Chem. Abs. vol. 38, col. 106.sup.3 (1944).
Elderfield; Heterocyclic Compounds, vol. 4, p. 288, (1952).
Crossley Roger
Curran Adrian Charles Ward
Hill David George
John Wyeth & Brother Ltd.
Rizzo Nicholas S.
Vaughn Mary C.
Wilfond Arthur E.
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