Certain 4-phenoxy-3-heteroarylmethyl or ethyl sulfamyl benzoic a

Details Certain 4-phenoxy-3-heteroarylmethyl or ethyl sulfamyl benzoic a Certain 4-phenoxy-3-heteroarylmethyl or ethyl sulfamyl benzoic a

1975-03-17

1976-08-03

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603322A, 2603472, 2602949, 260302R, 260309, 260465D, 2605011, 26050117, 260515M, 260516, 260519, 424263, 424275, 424285, C07D21328

Patent

active

039728862

ABSTRACT:
Compounds of the general formula ##SPC1##
In which R.sub.1 represents a straight or branched C.sub.1 -C.sub.6 alkyl, alkenyl or alkynyl radical, or a C.sub.1 -C.sub.3 alkyl radical substituted with phenyl, halophenyl, trifluoromethylphenyl, (lower alkoxy)phenyl, or with a 5-membered or 6-membered heterocyclic ring containing not more than two heteroatoms selected from the group consisting of oxygen, sulphur and nitrogen; R.sub.2 stands for a phenyl radical, optionally being substituted with halogen, lower alkyl, hydroxy, or lower alkoxy; X and Y stand for oxygen or sulphur; their salts and esters and methods for their preparation. The compounds of the invention possess an outstanding diuretic and saluretic activity with a very low excretion of potassium ions and a low toxicity.

REFERENCES:
patent: 3755383 (1973-08-01), Feit et al.
patent: 3758522 (1973-09-01), Feit et al.
patent: 3897476 (1975-07-01), Feit et al.

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