Certain 3-phosphinyl-amino-2-oxo-1H-azocine or azonine-1-acetic

Details Certain 3-phosphinyl-amino-2-oxo-1H-azocine or azonine-1-acetic Certain 3-phosphinyl-amino-2-oxo-1H-azocine or azonine-1-acetic

1984-11-28

1986-07-01

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 89, 514 91, 546 24, 549 6, 260239B, C07F 965, A61K 31395

Patent

active

045980713

ABSTRACT:
Phosphonamide substituted lactams of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents.

REFERENCES:
patent: 4379146 (1983-04-01), Greenlee et al.
patent: 4409146 (1983-10-01), Thorsett et al.
patent: 4432971 (1984-02-01), Karanewsky et al.
Brenner et al., "Eine Einbache Synthese von L-Lysin", Helv. Chem. Acta, vol. 41, pp. 181-188 (1958).
Blicke et al., "The Preparation of Basic Alcohols . . . ", J. Am. Chem. Soc., vol. 76, pp. 2317-2322 (1954).
Wilson et al., "Stereochemistry, Conformational Analysis . . . ", J. Org. Chem., vol. 44, pp. 330-336 (1979).
Nagasawa et al., "Medium Ring Homologs of Proline . . . ", J. Med. Chem., vol. 14, pp. 501-508 (1971).

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