Certain 2-substituted 4-phenylquinoline-4-ols

Details Certain 2-substituted 4-phenylquinoline-4-ols Certain 2-substituted 4-phenylquinoline-4-ols

1976-01-07

1977-09-13

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260268BQ, 260283SY, 260287T, 260288CE, 260289H, 260289K, 424258, C07D21522, C07D21538

Patent

active

040481778

ABSTRACT:
The invention relates to quinoline derivatives of the formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts of those compounds capable of forming acid addition salts. In formula (I), R.sup.1 and R.sup.2 which may be the same of different each represent hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halogen, R.sup.3 and R.sup.4 which may be the same or different each represent lower alkyl and X represents hydroxy, halogen, hydrazino, or a radical of formula -NR.sup.5 R.sup.6 where R.sup.5 and R.sup.6 which may be the same or different each represent hydrogen or lower alkyl or R.sup.5 and R.sup.6 together with the nitrogen atom to which they are both attached represent a saturated heterocyclic ring containing 5 to 7 ring atoms. The compounds possess hypotensive activity.

REFERENCES:
patent: 3493590 (1970-02-01), Plostnieks
patent: 3647802 (1972-03-01), Carney
Carney; Chem. Abst., vol. 74:53559y, (1967).

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