Certain 2-substituted 1,3-propylidenediphosphonate derivatives,

Details Certain 2-substituted 1,3-propylidenediphosphonate derivatives, Certain 2-substituted 1,3-propylidenediphosphonate derivatives,

1985-07-16

1987-09-29

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514100, 514102, 514107, 546 22, 2605024P, 549220, 558161, 558162, 558163, C07F 958, C07F 940, A61K 31675, A61K 3166

Patent

active

046969209

ABSTRACT:
2-Substituted-1,3-propylidenediphosphonates of formula (I), where A, R.sup.1 and R.sup.2 are defined in claim 1, are therapeutically active compounds, namely for the treatment of cardiovascular diseases.
They can be prepared by reacting phosphonating agents with 1,3- dibromopropanes or ditosylates of 1,3-propanediols substituted in position 2. ##STR1## .

REFERENCES:
patent: 3256370 (1966-06-01), Fitch et al.
patent: 3420917 (1969-01-01), Wu
patent: 4309364 (1982-01-01), Bentzen et al.
patent: 4371527 (1983-02-01), Bentzen et al.
patent: 4416877 (1983-11-01), Bentzen et al.

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