Certain 2-(phenyl sulfinylmethyl or ethyl) pyridine derivatives,

Details Certain 2-(phenyl sulfinylmethyl or ethyl) pyridine derivatives, Certain 2-(phenyl sulfinylmethyl or ethyl) pyridine derivatives,

1981-02-09

1982-04-27

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546339, C07D21334, A61K 3144

Patent

active

043271022

ABSTRACT:
The invention provides a compound of formula I ##STR1## wherein R represents hydrogen, lower alkyl, phenyl, halophenyl, loweralkylphenyl, loweralkoxyphenyl or aralkyl of 7 to 12 carbon atoms, R.sup.1 represents hydrogen or fluorine, R.sup.2 represents hydrogen, fluorine, chlorine or trifluoromethyl, n is 1 or 2 or pharmaceutically acceptable acid addition salt thereof.
Pharmaceutical compositions containing the compounds are also covered as are methods of treating ulcers or hypersecretion using the compounds. Corresponding thiocompounds, useful as intermediates, are also disclosed.

REFERENCES:
patent: 2826584 (1958-03-01), Cislak
Plant et al., Chemical Abstracts, vol. 85, No. 15, 108,543y, Oct. 11, 1976.
Bauer et al., Journal of Organic Chemistry, vol. 28, pp. 1323-1328, (1963).

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