Certain 2,4-diamino-5-(2,3,5-TRI-chlorophenyl)-6-substituted-pyr

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544325, A61K 31405, C07D23948

Patent

active

055873804

ABSTRACT:
A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a range of CNS disorders including cerebral ischaemic damage and epilepsy.

REFERENCES:
patent: 2624731 (1953-01-01), Hitchings et al.
patent: 4006235 (1977-02-01), Stickney et al.
Russell et. al., J.A.C.S., vol. 73, pp. 3763-3770 (1951).
Falco et. al., British J. of Pharmacology, vol. 6., pp. 185-200 (1951).

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