Certain 1H-pyrrold[3,4-b]quinolin-1-one-9-amino-2,3-dihydro deri

Details Certain 1H-pyrrold[3,4-b]quinolin-1-one-9-amino-2,3-dihydro deri Certain 1H-pyrrold[3,4-b]quinolin-1-one-9-amino-2,3-dihydro deri

1987-04-29

1990-12-04

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 82, 546 83, 546 84, C07D47104, A61K 3144

Patent

active

049754351

ABSTRACT:
The present invention comprises certain quinoline lactams of formula I; pharmaceutically acceptable salts of the compounds of formula I; pharmaceutical compositions containing a compound of formula I, or a pharmaceutically acceptable salt thereof, for use in the treatment of anxiety; and processes for the manufacture of the compounds of formula I, as well as intermediates for use in such manufacture.

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patent: 4631286 (1986-12-01), Shutske et al.
patent: 4705793 (1987-11-01), Resch
Marvel et al., Org. Syn., Coll., vol. I, 327 (1951).
Bedford et al., J. Chem. Soc., 1633-1634 (1959).
Klein et al., Tet. Letters, 22, 25-28 (1981).
Yamazaki et al., Chem. and Pharm. Bull., 30, 2357-2363 (1982).
Patel et al., Pharmacology Biochemistry and Behavior, 12:819-821 (1980).
Soviet Inventions Illustrated, CH Section, Week 8416, May 30, 1984.

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