Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1982-02-12
1983-08-02
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4242485, 424267, 424274, 544159, 544398, 546232, 548569, A61K 3154, C07D29510, A61K 31395
Patent
active
043966225
ABSTRACT:
Pharmaceutical compositions which comprise a compound of the formula (I): ##STR1## or a salt thereof wherein NR.sub.2 represents a piperidyl, pyrrolidyl, morpholino or N-methyl-piperazyl group any of which may substituted by one or two methyl groups; R.sup.1 represents fluorine, chlorine, bromine, iodine, lower alkoxyl, hydroxyl, acetoxyl, nitro, cyano, amino, dimethylamino, lower alkyl, trifluoromethyl, methylthio, ethylthio, methoxycarbonyl, ethoxycarbonyl, acetamido or carboxamido; R.sup.2 represents hydrogen, fluorine, chlorine, bromine, iodine, lower alkoxyl, hydroxyl, lower alkyl; R.sup.3 represents hydrogen, chlorine or lower alkyl; or R.sup.1 and R.sup.2 when on adjacent carbon atoms may together represent a polymethylene group containing from 3 to 5 carbon atoms; and n is 2, 3 or 4; and a pharmaceutically acceptable carrier, compounds of formula (I) except those wherein R.sup.1 is a 2-methoxyl group, and 2,4-dimethyl-1-[2-(4-bromophenylsulphonamido)ethyl]pyrrolidine and 2,4-dimethyl-1-[2-(4-bromophenylsulphonamido)ethyl]pyrrolidine, a process for the preparation of compounds of the formula (I) and 2,4-dimethyl-1-[2-(4-bromophenylsulphonamido)ethyl]pyrrolidine and 2,4-dimethyl-1[2-(4-iodophenylsulphonamido)ethyl]pyrrolidine as antiarrhythymic agents.
REFERENCES:
Moreau et al., Eur. J. Chem. Chemica Therapeutica Sep.-Oct. 1977, vol. 12(5) pp. 421-425.
Reynaud et al., Chimica Therapeutica (1971) vol. 6(1) pp. 25-41.
Silberg et al., Chem. Abstr., vol. 55 (1961), 4802i.
Dentz Bernard
Jiles Henry R.
Wuelfing Johann A.
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