Certain 1-phenyl-cyclobutane-1,3-dicarboxylic acid type compound

Details Certain 1-phenyl-cyclobutane-1,3-dicarboxylic acid type compound Certain 1-phenyl-cyclobutane-1,3-dicarboxylic acid type compound

1988-04-22

1989-08-15

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

549397, 549285, 549406, 556431, 556482, 560 19, 560 21, 560 37, 560 48, 562442, 562457, 562458, 562853, 562867, 562879, 552 6, 552 8, C07C 7946

Patent

active

048576603

ABSTRACT:
1-Phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula ##STR1## in which R.sub.1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R.sub.2 represents hydrogen, lower alkyl, sulpho or acyl, R.sub.3 represents hydrogen or lower alkyl and R.sub.4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by --N(R.sub.2)(R.sub.3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.

REFERENCES:
patent: 2673205 (1954-03-01), Hoffmann et al.
patent: 2848455 (1958-08-01), Hoffmann et al.
patent: 4131611 (1978-12-01), Fanshave et al.
patent: 4231935 (1980-11-01), Fanshave et al.
patent: 4435419 (1984-03-01), Epstein et al.
Alder et al, Helvetica Chimica Acta vol. 65, pp. 2405-2412 (1982).
Alder et al, J. Am. Chem. Soc. vol. 105, pp. 6712-6714 (1983).
Epstein et al, J. Med. Chem. vol. 24, pp. 481-490 (1981).

Affiliated with

Also associated with

Rating

Certain 1-phenyl-cyclobutane-1,3-dicarboxylic acid type compound does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Certain 1-phenyl-cyclobutane-1,3-dicarboxylic acid type compound, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Certain 1-phenyl-cyclobutane-1,3-dicarboxylic acid type compound will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-122861