Certain 1-hydroxyethane, 1,1-di-phosphonic acid derivatives usef

Details Certain 1-hydroxyethane, 1,1-di-phosphonic acid derivatives usef Certain 1-hydroxyethane, 1,1-di-phosphonic acid derivatives usef

1985-07-26

1987-08-18

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 80, 514 92, 514 93, 514 94, 548112, 548113, 548115, 546 22, C07F 958, C07F 965, A61K 3144, A61K 31415

Patent

active

046877673

ABSTRACT:
The present invention provides diphosphonates of the general formula: ##STR1## wherein Het is an imidazole, oxazole, isoxazole, thiazole, pyridine, 1,2,3-triazole, 1,2,4-triazole or benzimidazole radical, which is optionally substituted by alkyl, alkoxy, halogen, hydroxyl, carboxyl, an amino group optionally substituted by alkyl or alkanoyl radicals or a benzyl radical optionally substituted by alkyl, nitro, amino or aminoalkyl, A is a straight-chained or branched, saturated or unsaturated hydrocarbon chain containing 2 to 8 carbon atoms, X is a hydrogen atom, optionally substituted by alkanoyl, or an amino group optionally substituted by alkyl or alkanoyl radicals and R is a hydrogen atom or an alkyl radical; and the pharmacologically acceptable salts thereof.
The present invention also provides processes for the preparation of these diphosphonates and pharmaceutical compositions containing them.

REFERENCES:
patent: 4503049 (1985-03-01), Biere et al.

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