Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-09-09
1989-07-18
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514314, 514332, 514333, 546147, 546174, 546257, 546258, 546321, C07D21190, C07D40104, A61K 31455
Patent
active
048494291
ABSTRACT:
There is provided a dihydropyridine derivative having the formula ##STR1## wherein R'.sub.1 denotes methyl, chlorine, bromine, fluorine, trifluoromethyl, nitro, cyano or methoxy, R.sub.7 denotes benzyl; and the dihydropyridine links to the 2-, 3-, or 4-position of the pyridine.
The compound has an activity as a Ca-antagonist, and is useful for treating vascular disorders such as coronary artery disease, celebral artery disease, hypertension and the like.
REFERENCES:
patent: 3485847 (1969-12-01), Bossert et al.
patent: 3644627 (1972-02-01), Bossert et al.
patent: 3985758 (1976-10-01), Murakami et al.
patent: 4618607 (1986-10-01), Araki et al.
Chem. Abstracts, vol. 80 (1), Abst. No. 14958g, Jan. 7, 1974.
Chem. Abstracts, vol. 96 (23), Abst. No. 96:199, 719b, Jun. 7,1982.
The Merck Index, 10th Ed., pp. 6368, 6335.
Ashimori Atsuyuki
Fukaya Chikara
Ono Taizo
Yokoyama Kazumasa
Rotman Alan L.
The Green Cross Corporation
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