Cerebrospinal and vascular pharmaceutical composition and...

Details Cerebrospinal and vascular pharmaceutical composition and... Cerebrospinal and vascular pharmaceutical composition and...

2000-02-26

2008-11-04

Weber, Jon P (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S011400, C530S317000

Reexamination Certificate

active

07446093

ABSTRACT:
A cyclosporin-containing pharmaceutical preparation for cerebrospinal or vascular application is disclosed, comprising (1) at least one cyclosporin, and (2) DMSO.

REFERENCES:
patent: 4649047 (1987-03-01), Kaswan
patent: 5221607 (1993-06-01), Cordell et al.
patent: 5252463 (1993-10-01), Nelson et al.
patent: 5807820 (1998-09-01), Elias
patent: 5811410 (1998-09-01), Falk et al.
patent: 5827834 (1998-10-01), Falk et al.
Lebel et al., Int. Arch. Allergy. Immunol., vol. 116, pp. 284-287, 1998.
Kessler te al., Biochemical Pharmcaology, vol. 40, No. 1, pp. 169-173, 1990.
Ezzel, Scientific America, pp. 152-153, Mar. 7, 1993.
Varon et al., Dev. Neurosci., vol. 6, pp. 73-100, 1983/1984.
Okonkwo et al. An Intrthecal Bolus of Cyclosporin A Before Injury Preserves Mitochohdrial Integrity and Attenuates Axonal Disruption in Traumatic Brain Injusry, 1999, J. cereb. Blood Flow Metab., vol. 19, No. 4, pp. 443-451.
Pubmed Abstract 9693278, Lebel et al., “Inhibition of mediator release from dispersed nasl polyp cells by cyclosporin A,” Aug. 1998, Int Arch Allery Immunol, vol. 116, No. 4, pp. 284-287.
Pubmed Abstract 2164815, Kessler et al., “Complexation and medium effects on the conformation of cyclosporin A studied by NMR spectroscopy and molecular dynamics calculation,” Jul. 1, 1990, Biochem Pharmacol, vol. 40, No. 1, pp. 169-173.
Shimizu et al., “Dimethylsulfoxide (DMSO) treatment reduces infarction vol. after permanent focal cerebral ishchemia in rats,” Neuroscience Letters, vol. 239, No. 2-3, Dec. 19, 1997, pp. 125-127, XP-002316700.
Elzinga et al., “The Effect of Dimethyl Sulfoxide on the Absorption of Cyclosporine in Rats,” Transplantation, vol. 47, No. 2, Feb. 1989, pp. 394-395, XP009043582.
Broadwell et al., “Morphologic Effect of Dimethyl Sulfoxide in the Blood-Brain Barrier,” Science, vol. 217, No. 4555, Jul. 9, 1982, pp. 164-166, XP009043581.

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