Cerebral vasodilator eburnane derivatives

Details Cerebral vasodilator eburnane derivatives Cerebral vasodilator eburnane derivatives

1981-04-30

1983-05-10

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546 51, A61K 31435, C07D46100

Patent

active

043829368

ABSTRACT:
A compound of the formula: ##STR1## wherein R.sup.1 is a C.sub.1 -C.sub.6 alkyl group and R is a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group, and their salts, which are useful as cerebral vasodilator; and a compound of the formula: ##STR2## wherein R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group, R.sup.3 is a hydrogen atom or the formula: --CO.sub.2 R.sup.1 (R.sup.1 is a C.sub.1 -C.sub.6 alkyl group) and W is an oxygen atom, an imino group or ##STR3## but not an imino group in case that R.sup.3 is a hydrogen atom, which are intermediates of the compound (I), useful per se as cerebral vasodilator and/or antihypertensive agents.

REFERENCES:
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patent: 3830823 (1974-08-01), Castaigne
patent: 3852453 (1974-12-01), Giudicelli et al.
patent: 3925393 (1975-12-01), Hertaux et al.
patent: 3937709 (1976-02-01), Sevenet et al.
patent: 4035370 (1977-07-01), Lorincz et al.
patent: 4057550 (1977-11-01), Szantay et al.
patent: 4190658 (1980-02-01), Warnant et al.
patent: 4316028 (1982-02-01), Katsube et al.
Loerincz, et al., Chemical Abstracts, vol. 79, 18934y (1973).

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