Cerebral vasodilating 20,21-dinoreburnamenine derivatives

Details Cerebral vasodilating 20,21-dinoreburnamenine derivatives Cerebral vasodilating 20,21-dinoreburnamenine derivatives

1980-04-07

1981-09-22

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546 51, A61K 31445, C07D46100

Patent

active

042910382

ABSTRACT:
New 20,21-dinoreburnamenine derivatives are disclosed which have the formula I ##STR1## wherein the hydroxyl in the 14-position of the molecule is in either of the two possible positions at the carbon atom in the 14-position to which the isomers A and B correspond and the hydrogens in the 3-position and the 16-position of the molecule are in cis- or in trans-position to each other, and their pharmaceutically acceptable acid addition salts, as well as pharmaceutical formulations thereof.
The new compounds of formula I are prepared by reducing the corresponding 14-oxoderivatives. They are effective in favorably influencing the cerebral vascular circulation.

REFERENCES:
patent: 3542796 (1970-11-01), Schut
patent: 3755335 (1973-08-01), Thal et al.
Aurousseau, M., Eur. J. Med. Chem.-Chim. Ther., 6, 221-234 (1971).

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