Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
1999-09-20
2011-10-18
Ulm, John (Department: 1649)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
08039586
ABSTRACT:
A cerebral organic anion transporter OAT3 which is useful as a protein regulating the uptake/excretion of organic anionic substances in the brain; a nucleic acid having a base sequence encoding the same; and an antibody against the same. The amino acid sequence and the base sequence of the above OAT3 are shown in Sequence Listing in the description.
REFERENCES:
patent: WO 97/42321 (1997-11-01), None
patent: WO 01/04283 (2001-01-01), None
T. Sekine et al., “Expression Cloning and Characterization of a Novel Multispecific Organic Anion Transporter,” J. Biol. Chem., vol. 272, No. 30, Jul. 1997, pp. 18526-18529.
C. Heaney et al., “Human autosomal recessive osteopetrosis maps to 11q13, a position predicted by comparative mapping of the murine osteosclerosis (oc) mutation,” Human Mol. Genetics, 1998, vol. 7, No. 9, pp. 1407-1410.
J. Race et al., “Molecular Cloning and Characterization of Two Novel Human Renal Organic Anion Transporters (hOAT1 and hOAT3),” BioChem. & Biophys. Research Communications, 255, 1999, pp. 508-514.
K. Brady et al., “A Novel Putative Transporter Maps to the Osteosclerosis (oc) Mutation and Is Not Expressed in the Mutant Mouse,” Genomics, 56, 1999, pp. 254-261.
M. Hosoyamada et al., “Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney,” Am. J. Physiology, vol. 276, No. 1 part 2, Jan. 1999, pp. F122-F128.
H. Endou, “Recent advances in molecular mechanisms of nephrotoxicity,” Toxicology Letters, Elsevier Biomedical Press, vol. 102/103, Dec. 1998, pp. 29-33.
Kusuhara et al., “Characterization of Efflux Transport of Organic Anions in a Mouse Brain Capillary Endothelial Cell Line,” The Journal of Pharmacology and Experimental Therapeutics 285:1260-1265 (1998).
Noé et al., “Isolation of a Multispecific Organic Anion and Cardiac Glycoside Transporter from Rat Brain,” Proc. Natl. Acad. Sci. USA 94:10346-10350 (1997).
Endou et al. “Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain”, J. Biol. Chem (May 1999) p. 13675-13680.
Endou et al. “Identification of multispecific organic anion transporter 2 expressed predominantly in the liver”, FEBS Letters (Jun. 1998) p. 179-182.
XP002214544—Online Search: C. Heaney et al., “Mus musculus reduced in osteosclerosis transporter (Roct) mRNA, complete cds”, (1998) Database Accession No. AF078869.
XP002214546—Online Search: R. Strausberg, “Homo sapiens cDNA clone Image:2527728 3′ similar to TR:088909 088909 reduced in osteosclerosis transporter; mRNA sequence”, (1999), Database Accession No. AW025165.
XP002214545—Online Search: R. Strausberg et al., “Homo sapiens cDNA clone Image:1323232 3′, mRNA sequence”, (1998), Database Accession No. AA877205.
XP002225616—Online Search: M. Marra et al., “Mus musculus cDNA clone Image: 572103 5′ similar to TR: G1293672 G1293672 Kidney-specific transport protein; mRNA sequence”, (1996), Database Accession No. AA108584.
Partial European Search Report for EP 99 94 3423 dated Oct. 16, 2002.
Supplmentary European Search Report for EP 99 94 3423 dated Jan. 22, 2003.
Endou Hitoshi
Kusuhara Hiroyuki
Sekine Takashi
Corless Peter F.
Edwards Angell Palmer & & Dodge LLP
J-Pharma Co., Ltd.
O'Day Christine C.
Ulm John
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