Cerebral function enhancing diazinylpiperidine derivatives

Details Cerebral function enhancing diazinylpiperidine derivatives Cerebral function enhancing diazinylpiperidine derivatives

1987-08-28

1989-05-02

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514253, 514269, 514273, 514274, 514275, 514256, 544238, 544320, 544321, 544327, 544329, 544332, 544336, 544408, 544409, 544311, 544312, 544316, 544317, C07D40114, A61K 31445, A61K 31505, A61K 3150

Patent

active

048268437

ABSTRACT:
A series of diazinylpiperidine compounds of Formula I ##STR1## wherein X is an ethylene chain or a 1,2-benzo ring; Y is carbonyl or methylene; R.sup.1 is hydrogen or lower alkyl; and Z is an R.sup.2, R.sup.3 -disubstituted diazinyl ring selected from pyridazine, pyrimidine, and pyrazine ring systems. Pharmacologic and neuroanatomical testing demonstrates that compounds of the series act to enhance cerebral function in mammals, particularly when there is a deficit in normal cerebral functioning. Specific pharmacologic test results indicate that compounds of Formula I possess cognition and memory enhancing activity.

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patent: 4668687 (1987-05-01), Yevich et al.
Butler, et al., J. Med. Chem., 27, pp. 684-691 (1984) (3/13).
Malawska, et al., Polish Journal of Pharmacology, 34, pp. 373-382 (1982) (5/4).

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