Cerebral function enhancers: acyclic amide derivatives of pyrimi

Details Cerebral function enhancers: acyclic amide derivatives of pyrimi Cerebral function enhancers: acyclic amide derivatives of pyrimi

1993-04-19

1994-08-16

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544322, C07D40104, A61K 31505

Patent

active

053387384

ABSTRACT:
A series of acyclic amide derivatives of pyrimidinylpiperazines of Formula I ##STR1## wherein R.sup.1 is alkyl, phenalkyl, phenyl-hydroxyalkyl, phenyl and pyridinyl; R.sup.2 and R.sup.3 are hydrogen and alkyl; and R.sup.4 is hydrogen, halogen, and trifluoromethyl.
Compounds of the invention can be incorporated into pharmaceutical compositions for use in enhancing cerebral function. The compounds are envisioned as being useful in restoration of cerebral function in degenerative disorders; in amnesia reversal; and in improvement of memory and learning processes.

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Malawska, et al., "Synthesis and Pharmacological Properties of Some 2-Pyrrolidinone Mannich Bases", Polish Journal of Pharmacology, 34, pp. 373-382 (1982).

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