Ceramide glucosyltransferase

Details Ceramide glucosyltransferase Ceramide glucosyltransferase

1996-06-14

1998-07-14

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C12N 910

Patent

active

057802840

ABSTRACT:
The subject invention provides a novel ceramide glucosyltransferase having catalytic activity of glucose transfer from UDP-Glc to ceramide, and a nucleic acid sequence encoding the ceramide glucosyltransferase.

REFERENCES:
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Durieux et al. (Apr. 1990) Comparative Effects of Sulfhydryl Reagents on Membrane-Bound and Solubilized UDP-Glucose:ceramide Glucosyltransferase from Golgi Membranes. Evidence for Partial Involvement of a Thiol Group in the Nucleotide Sugar Binding Site of th.
Ngo et al. (Jan. 1994) Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox, In The Protein Folding Problem and Tertiary Structure Prediction, Eds. Merz et al., Birkhauser, Boston, MA, pp. 491-495.
Schulte et al. (Nov. 1993) Ceramide UDP-galactosyltransferase from myelinating rat brain: Purification, cloning, and expression, Proc. Natl. Acad. Sci. USA 90: 10265-10269.
Paul et al. (Jan. 26,1996) Purification and Characterization of UDP-glucose:Ceramide Glucosyltransferase from Rat Liver Golgi Membranes, J. Biol. Chem. 271 (4): 2287-2293.
Ichikawa et al. (May 1996) Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis, Proc. Natl. Acad. Sci. USA 93: 4638-4643.
Vunnam et al. (Jan. 1979) Short chain ceramides as substrates for glucocerebroside synthetase, Biochimica et Biophysica Acta 573: 73-82.

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