Ceramide analogs, process for their preparation and their...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S225000, C544S242000, C536S001110, C536S004100, C514S023000, C514S025000, C514S027000

Reexamination Certificate

active

10919867

ABSTRACT:
The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumors

REFERENCES:
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patent: WO 96/20710 (1996-07-01), None
patent: WO 98/52948 (1998-11-01), None
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Kinloch et al., “The Pharmacology of Apoptosis,” Trends Pharm. Sci. 20:35-42, 1999.
Macchia et al., “Geranylgeranyl Diphosphate-Based Inhibitors of Post-Translational Geranylgeranylation of Cellular Proteins,” J. Med. Chem. 39:1352-1356, 1996.
Pless et al., “Boron Tris (trifluoracetate) for Removal of Protecting Groups in Peptide Chemistry,” Angew. Chem. Int. Ed. 12:147-148, 1973.
Talbot et al., Synthesis of 4-Aminobutyric Acid and 2,4-Diaminobutyric Acid from Butyrolactone,: Can. J. Chem. 36:593-596, 1958.
Sakai et al., “Ceramide Derivatives for Therapeutic Agents,” Exp. Opin. Ther. Patents 8:1673-1682, 1998.

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