Ceramide analogs, process for their preparation and their...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S001110, C514S023000, C514S025000, C514S027000, C544S001000, C544S224000, C544S242000

Reexamination Certificate

active

06956109

ABSTRACT:
The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumors.

REFERENCES:
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patent: WO 96/20710 (1996-07-01), None
patent: WO 98/52948 (1998-11-01), None
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Kinloch et al., “The Pharmacology of Apoptosis,” Trends Pharm. Sci. 20:35-42, 1999.
Macchia et al., “Geranylgeranyl Diphosphate-Based Inhibitors of post-Translational Geranylgeraylation of Cellular Proteins,” J. Med. Chem. 39:1352-1356, 1996.
Pless et al., “Boron Tris (trifluoroacetate) for Removal of Protecting Groups in Peptide Chemistry,” Angew. Chem. Int. Ed. 12:147-148, 1973.
Talbot et al., “Synthesis of 4-Aminobutyric Acid and 2,4-Diaminobutyric Acid From Butyrolactone,” Can. J. Chem. 36:593-596, 1958.
Sakai et al., “Ceramide Derivatives for Therapeutic Agents,” Exp. Opin. Ther. Patents 8:1673-1682, 1998.

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