Ceramidase gene

Details Ceramidase gene Ceramidase gene

2005-01-25

2005-01-25

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S252300, C435S320100, C536S023200, C530S350000

Reissue Patent

active

RE038689

ABSTRACT:
To provide a polypeptide having ceramidase activity, and a gene encoding thereof useful as an reagent for lipid engineering and as indices for diagnosis of atopic dermatitis, an easy method for detecting the polypeptide and method for detecting the gene as well as a method for detecting atopic dermatitis. A polypeptide having an amino acid sequence as shown in SEQ ID NO: 1 in Sequence Listing, or a polypeptide having an amino acid sequence which has substitution, deletion, addition or insertion of one or more amino acids in the amino acid sequence of SEQ ID NO: 1 and having ceramidase activity; a gene encoding the polypeptide; a gene capable of hybridizing with the above genes under stringent conditions, and encoding a polypeptide having ceramidase activity; an oligonucleotide probe or primer, which is capable of hybridizing under stringent conditions with the above genes or with a gene having a nucleotide sequence complementary thereto; a method for detecting a gene encoding a polypeptide having ceramidase activity, by using the oligonucleotide probe and/or primer; an antibody or a fragment thereof, which is capable of specifically binding to the polypeptide; a method for detecting a polypeptide having ceramidase activity, by using the above antibody or fragment thereof; a method for detecting atopic dermatitis, by the methods.

REFERENCES:
patent: 1014563 (1998-01-01), None
Koch et al. J. Biol. Chem. 271 (51):33110-5, Dec. 20, 1996.*
N. Okino et al., Purif. and Char. of a Novel Ceramidase fromPseudomonas aeruginosa, J. Biol. Chem.,273:14368-14373, 1998.*
Jurgen Koch et al., Molecular Cloning and Characterization of a Full-length Complementary DNA Encoding Human Acid Ceramidase,J. Biol. Chem.,271(51):33110-33115, 1996.*
Chi-Ming Li et al., Cloning and Cloning and Characterization of the Full-Length cDNA and Genomic Sequences Encoding Murine Acid Ceramidase,Genomics50:267-274, 1998.*
Suggs et al.,PNAS78 (11):6613-6617, 1981.*
Edman et al.,Eur. J. Biochem.1:80-91, 1967.

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