Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Reexamination Certificate
2008-04-29
2008-04-29
Hartley, Michael G. (Department: 1618)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
C424S489000, C424S495000, C424S499000, C514S009100, C514S171000, C514S178000
Reexamination Certificate
active
10764677
ABSTRACT:
The present invention provides methods and compositions for photodynamic therapy. The composition comprises ceramic nanoparticles in which a photosensitive drug/dye is entrapped. The ceramic nanoparticles are made by formation of a micellar composition of the dye. The ceramic material is added to the micellar composition and the ceramic nanoparticles are precipitated by alkaline hydrolysis. The precipitated nanoparticles in which the photosensitive dye/drug is entrapped can be isolated by dialysis. The resulting drug doped nanoparticles are spherical, highly monodispersed, and stable in aqueous system. Irradiation with light of suitable wavelength of the photosensitizing drug entrapped inside nanoparticles resulted in generation of singlet oxygen, which was able to diffuse out through the pores of the ceramic matrix. The drug loaded ceramic nanoparticles of the present invention can be used as drug carriers for photodynamic therapy.
REFERENCES:
Tapan Kumar Jain, Indrajit Roy, Tapas K. De, and Amarnath Maitra; Nanometer silica particles encapsulating active compounds: A Novel ceramic drug carrier, J. Am. Chem. Soc. 120, 11092-11095, 1998.
Arriagada, et al.,Synthesis of Nanosize Silica in Aerosol OT Reverse Microemulsions, Journal of Colloid and Interface Science, 1995, 170, pp. 8-17.
Nass, et al.,Synthesis of an alumina coating from chelated aluminium alkoxides, Journal of Non-Crystalline Solids, May 1, 1990, V. 121, Issues 1-3, pp. 329-333.
Badley, et al.,Surface Modification of Colloidal Silica, Langmuir, 1990, 6, pp. 792-801.
Lal, et al.,Silica Nanobubbles Containing an Organic Dye in a Multilayered Organic/Inorganic Heterostructure with Enhanced Luminescence, Chem. Mater, 2000, V. 12, pp. 2632-2639.
Kumar, et al.,Nanometer Silica particles Encapsulating Active Compounds: A Novel Ceramic Drug Carrier, J. Am. Chem. Soc., 1998, 120, pp. 11092-11095.
Avnir, et al.,Enzymes and Other Proteins Entrapped in Sol-Gel Materials, Chem. Mater., 1994, 6, pp. 1605-1614.
Taillefer, et al.,In-vitro and in-vivo evaluation of pH-responsive polymeric micelles in a photodynamic cancer therapy model,Journal of Pharmacy and Pharmacology, 2001, 53, pp. 155-166.
Chang, et al.,Kinetics of Silica Particle Formation in Nonionic W/O Microemulsions from TEOS, AIChE Journal, Nov. 1996, vol. 42, No. 11, pp. 3153-3163.
Bergey Earl J.
Ohulchansky Tymish Y.
Prasad Paras
Pudavar Haridas
Roy Indrajit
Hartley Michael G.
Hodgson & Russ LLP
Research Foundation of the State University of New York
Samala Jagadishwar
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