Cephem compounds, and antibacterial agents

Details Cephem compounds, and antibacterial agents Cephem compounds, and antibacterial agents

1991-10-11

1993-09-14

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540226, 540227, C07D50120, A61K 31545

Patent

active

052448924

ABSTRACT:
Novel cephem compounds represented by a formula [I] and pharmacologically admissible salts or capable of physiologically hydrolyzable nontoxic esters thereof are disclosed. ##STR1## [wherein R.sup.1 indicates a straight-chain or branched lower alkyl group, which may be substituted by carboxyl group which may be protected, trityl group, hydrogen atom or fluorine-substituted lower alkyl group, R.sup.2 indicates a hydrogen atom, metal atom, protective group for carboxyl group or ester residue producible hydrolyzable ester in vivo, R.sup.3, R.sup.4, R.sup.5 and R.sup.6, which may be identical or different, indicate hydrogen atoms, halogen atoms, straight-chain or branched lower alkyl groups, which may be substituted, mercapto groups, which may be substituted, lower alkylamino groups, hydroxyl groups, which may be protected, lower alkoxy groups, lower alkanoyl groups, lower alkoxycarbonyl groups, or lower alkylenedioxy groups, which may be substituted, being maybe formed with R.sup.3 and R.sup.4, R.sup.7 indicates a hydrogen atom, cyano group, halogen atom or COOR.sup.8 (R.sup.8 is hydrogen or lower alkyl group), R.sup.9 indicates an amino group, which may be protected, Z indicates N or CH, and n indicates 0 or 1].
Preparation processes for them and antibacterial agents containing them as effective ingredients are also claimed.

REFERENCES:
patent: 3904618 (1975-09-01), Pioch
patent: 4513149 (1989-04-01), Megi et al.
patent: 4546176 (1989-10-01), Maduda et al.
patent: 5057511 (1991-10-01), Jung et al.
Journal of the American Chemical Society, 90:2, Jan. 17, 1968.
J. Org. Chem., vol. 35, No. 7, 1970.
J. Antibiotics, 38, 1738 (1985). Synthetic Communications, 16(9), 1029-1035 (1986).
Tetrahedron Lett., 22, 3915 (1985).
Chem. Pharm. Bull., 35, 3115 (1977).
Tetrahedron, 34, 725 (1978).
J. Natl. Pro., 53, 50 (1990).
JCS Perkin Trans I, 837 (1980).

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