Cephem compounds

Details Cephem compounds Cephem compounds

1988-06-07

1990-03-27

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540221, 540222, 540226, C07D50126, A61K 31545

Patent

active

049122126

ABSTRACT:
Broad spectrum antibiotics are provided which are compounds of the formula: ##STR1## wherein -W-R is a residue of a nucleophilic compound and R.sup.5 is hydroxyl or protected hydroxyl, or a pharmaceutically acceptable salt or 4-carboxy ester which is the alkoxymethyl, .alpha.-alkoxyethyl, .alpha.-alkoxy-.alpha.-substituted methyl, alkylthiomethyl, acyloxymethyl or .alpha.-acyloxy-.alpha.-substituted methyl ester thereof.

REFERENCES:
patent: 3971778 (1976-07-01), Cook et al.
patent: 4308380 (1981-01-01), Kamiya et al.
patent: 4668783 (1987-05-01), Ochiai et al.
Patent Status of Case No. 0772-Feb. 13, 1989.
Chemical Abstract Vol. 85: 177458m.
Chemical Abstract Vol. 93: 239439g.
Chemical Abstract Vol. 94: 103392z.
Chemical Abstract Vol. 98: 4538c.
Chemical Abstract Vol. 98: 34944z.
Chemical Abstracts, Vol. 98: 160699m.

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