Cephapirine esters and salts thereof

Details Cephapirine esters and salts thereof Cephapirine esters and salts thereof

1981-03-05

1983-07-12

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 23, C07D50134

Patent

active

043932053

ABSTRACT:
Cephapirine esters having the formula ##STR1## wherein R is selected from the group consisting of ##STR2## Such esters and salts thereof, having antibiotic activity, are prepared by reacting 7-ACA with bromophtalide or chloromethylpivalate in the presence of an alkylamine, at a temperature in the range of 0.degree.-70.degree. C. The reaction compound is reacted with chlorohydrate chloride of 4-piridylthioacetic acid. A salt of the compound of formula (I) is isolated from the reaction mixture, after washing with acidic water and addition of a pharmaceutically acceptable acid, by treatment with a suitable solvent.

REFERENCES:
patent: 3422100 (1969-01-01), Crast
patent: 3578661 (1971-05-01), Havtranek et al.
patent: 4036829 (1977-07-01), Ferres et al.

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