Cepham compounds

Details Cepham compounds Cepham compounds

1981-08-03

1983-02-22

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 21, 544 22, 424246, 424271, C07D50104, A61K 31545

Patent

active

043749828

ABSTRACT:
Penicillin sulfoxide esters are reacted with an isocyanate to produce the corresponding (substituted)-2-carbamoyloxymethylpenam, the corresponding (substituted)-3-carbamoyloxycepham or the corresponding 3-methylcephem. The 6- or 7-side-chain of these products may be cleaved to give the corresponding 6-amino (penams) or 7-amino (cephams and cephems) compounds, and the latter may be reacylated to produce different 6-acyl-2-carbamoyloxymethyl penams, 7-acyl-3-carbamoyloxy cephams and 7-acyl-3-methylcephems. The substituent groups may be removed from the (substituted)-2-carbamoyloxypenams or the (substituted)-3-carbamoyloxycephams to give the corresponding free 2-carbamoyloxymethylpenams or 3-carbamoyloxycephams, respectively.

REFERENCES:
patent: 3275626 (1966-09-01), Morin et al.
patent: 3714156 (1973-01-01), Rapoport
patent: 3997533 (1976-12-01), Kabbe et al.
patent: 4010156 (1977-03-01), Nodelman et al.
patent: 4084049 (1978-04-01), Kamiya et al.
patent: 4182711 (1980-01-01), Veda
patent: 4218374 (1980-08-01), Kamiya et al.
patent: 4254029 (1981-03-01), Kaspi et al.
patent: 4264597 (1981-04-01), Hashimoto et al.
patent: 4310459 (1982-01-01), Cundall et al.
patent: 4322347 (1982-03-01), Cundall et al.
Cooper et al., Accounts of Chemical Research, vol. 6, 1973, pp. 32-40.
Grant et al., J. Chem. Soc. (6) 1965, pp. 3842-3845.

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