Cephalosporins having an .alpha.-acylaminoacetic acid side chain

Details Cephalosporins having an .alpha.-acylaminoacetic acid side chain Cephalosporins having an .alpha.-acylaminoacetic acid side chain

1979-02-12

1981-05-05

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 22, 544 25, 544 27, 544 28, A61K 31545

Patent

active

042658926

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 denotes optionally substituted phenyl, thienyl, furyl or 1,4-cyclohexadienyl, R.sub.2 represents a free carboxyl group or an esterified carboxyl group which can be split physiologically, R.sub.3 represents hydrogen, lower alkoxy or an optionally substituted methyl group and B represents an optionally substitued six-membered ring with 1 to 3 ring nitrogen atoms, which is bonded to the carbonyl group --C(.dbd.O)-- by one of its carbon atoms, the nitrogen atoms of a monocyclic six-membered ring having 2 nitrogen atoms being either adjacent or separated by two ring carbon atoms, and the salts of such compounds which have a salt-forming group, including the inner salts, for example the 7.beta.-[D(-)-.alpha.-(3,5-Dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-c arboxamido)-phenylacetamido]-cephalosporanic acid, have antibiotic activity.

REFERENCES:
patent: 4041161 (1977-08-01), Kocsis et al.
patent: 4117126 (1978-09-01), Yamada et al.
patent: 4160087 (1979-07-01), Yamada et al.

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