Cephalosporins having a metaloxy group in 3-substituent

Details Cephalosporins having a metaloxy group in 3-substituent Cephalosporins having a metaloxy group in 3-substituent

1975-12-03

1978-05-30

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 4, 544 16, 544 21, 544 22, 544 29, 424246, C07D50116, C07D50134, C07D50128, A61K 31545

Patent

active

040924742

ABSTRACT:
Antibacterial cephalosporins of the formula ##STR1## wherein Acyl is an acyl group; R is a hydrogen or methoxy, R.sup.1 is a hydrocarbyl group containing 1 to 8 carbon atoms; R.sup.2 is a hydrogen, alkali metal, alkaline earth metal, halo-alkaline earth metal group or acyl group containing 1 to 12 carbon atoms; R.sup.3 is a hydrogen, pharmaceutically acceptable cation, or ester residue; or when R.sup.2 and R.sup.3 are both hydrogens, they can be combined to form a lactone ring; the broken line shows a double bond at position 2 or 3; and n is zero or one, and processes for preparing them by the reaction of the compound shown by above formula in which R.sup.1 and R.sup.2 combined to show a bond, with a Grignard type or organometallic reagent to introduce R.sup.1, followed by acylation, oxidation, reduction, double bond migration, or other reactions.

REFERENCES:
patent: 3351596 (1967-11-01), Chamberlin
patent: 3947413 (1976-03-01), Christensen et al.
patent: 3983113 (1976-09-01), Beeby
patent: 4012380 (1977-03-01), Spry

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