Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1977-09-30
1979-09-18
Wheeler, David
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544 22, 544 24, 544 25, 544 26, 544 27, A61K 31545, C07D50140
Patent
active
041683099
ABSTRACT:
Antibiotic compounds of the general formula ##STR1## [wherein R is a phenyl, thienyl or furyl group; R.sup.a and R.sup.b which may be the same or different, are each selected from hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.3-7 cycloalkyl, phenyl, naphthyl, thienyl, furyl, carboxy, C.sub.2-5 alkoxycarbonyl and cyano, or R.sup.a and R.sup.b together with the carbon atom to which they are attached form a C.sub.3-7 cycloalkylidene or cycloalkenylidene group; m or n are each 0 or 1 such that the sum of m and n is 0 or 1; and R.sup.1 together with the nitrogen atom to which it is attached form a saturated or partially saturated 4-10 membered heterocyclic ring which may contain one or more further heteroatoms selected from 0,N and S and which may be substituted by a lower alkyl, lower alkoxy, lower acyloxy, lower alkoxycarbonyl, hydroxy, carboxy, amino, acylamino, substituted or unsubstituted carbamoyl or aryl group, or such a heterocyclic ring fused with a benzene ring] and non-toxic derivatives thereof, the compounds being syn isomers or existing as mixtures of syn and anti isomers.
REFERENCES:
patent: 4074047 (1978-02-01), Foxton et al.
patent: 4095021 (1978-06-01), Bradshaw et al.
Glaxo Laboratories Limited
Wheeler David
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