Cephalosporins

Details Cephalosporins Cephalosporins

1982-01-06

1984-03-13

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 22, 544 25, 544 28, 548318, C07D50156

Patent

active

044369042

ABSTRACT:
Novel cephalosporin derivatives are described which have excellent antibiotic activity against pathogenic bacteria belonging to the Pseudomonas, Serratia and Enterobacter. The compounds have general formula ##STR1## in which R is hydrogen, acyloxy, carbamoyloxy, a substituted or unsubstituted pyridinium group or a group -S-Het in which Het represents a substituted or unsubstituted, hetero atom-containing, 5- or 6-membered heterocyclic ring, R' is hydrogen, alkali metal, an organic amine or an ester moiety, R.sub.1 and R.sub.2 are the same or different and are hydrogen or a lower alkyl and B stands for a 1,4-cyclohexadienyl group, a group ##STR2## in which Y is hydrogen, --OH or ##STR3## in which R.sub.5 is an alkyl of 1 to 5 carbon atoms, aryl or alkoxy having 1 to 4 carbon atoms, Z stands for hydrogen or halogen and p is an integer of 1 or 2, a furan group or a thiophene group. Methods of preparation are described.

REFERENCES:
patent: 4200576 (1980-04-01), Feyen et al.
patent: 4291160 (1981-09-01), Harrison et al.

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