Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1981-09-23
1984-12-18
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544 21, 544 22, 544 25, 544 27, 544 16, 544 30, A61K 31545, C07D50156
Patent
active
044890729
ABSTRACT:
Novel cephalosporins which has attached to the exomethylene group at the 3-position of the cephem ring a substituted or unsubstituted aryl, acylamino, aromatic heterocyclic, triazolyl or tetrazolyl group, said aromatic heterocyclic group being attached through a carbon-carbon bond and said triazolyl or tetrazolyl group being attached through a carbon-nitrogen bond, and has the following group attached to the amino group at the 7-position: ##STR1## wherein A represents a group of the formula, --CH.sub.2 -- or a group of the formula ##STR2## in which R.sup.5 represents a hydrogen atom or an alkyl group, and the bond represents syn or anti isomer or their mixture; R.sup.3 represents a hydrogen or halogen atom; and R.sup.4 represents a hydrogen atom or an amino group which may be protected or substituted. These cephalosporins have a broad antibacterial spectrum, are stable against .beta.-lactamase produced by bacteria, have a low toxicity, and are well absorbed when administered orally or parenterally.
This invention relates to such novel cephalosporins, processes for producing said cephalosporins, intermediates for producing said cephalosporins, and a process for producing said intermediates.
REFERENCES:
patent: 3274186 (1966-09-01), Barker et al.
patent: 3932465 (1976-01-01), Peter et al.
patent: 4278671 (1981-07-01), Ochiai et al.
patent: 4278793 (1981-07-01), Durckheimer et al.
patent: 4328225 (1982-05-01), Vignau et al.
Hirakawa Tatsuo
Imaizumi Hiroyuki
Inaba Takihiro
Konishi Yoshinori
Narita Hirokazu
Coughlan, Jr. Paul M.
Toyama Chemical Co., Ltd.
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