Cephalosporins

Details Cephalosporins Cephalosporins

1974-06-25

1977-02-15

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50136

Patent

active

040082270

ABSTRACT:
A compound of the formula: ##STR1## wherein R.sup.1 represents mandeloyl or 2-(3-sydnone)-acetyl group and R.sup.2 represents a hydrogen atom, a halogen, an alkyl or an alkoxyl group, or a pharmaceutically accetable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria as well as gram-positive ones. Examples thereof include 7-[D-(-)-mandelamido]-3-[6'-(3'-methylpyridazinyl)-thio-methyl]-3-cephem-4 -carboxylic acid 2'-oxide, 7-[D-(-)-mandelamido]-3-[6'-(3'-methoxypyridazinyl)-thiomethyl]-3-cephem-4 -carboxylic acid 1'-oxide, and 7-[2'-(3'-sydnone)acetamido]-3-[6"-(3"-methylpyridazinyl)-thiomethyl]-3-ce phem-4-carboxylic acid 2"-oxide.

REFERENCES:
patent: 3855213 (1974-12-01), Dunn et al.
patent: 3878204 (1975-04-01), Ochiai et al.
patent: 3890309 (1975-06-01), Ochiai et al.
patent: 3892737 (1975-07-01), Ochiai et al.
Culvenor, (Amine Oxides), Reviews of Pure and Applied Chemistry, vol. 3 (1953) pp. 83-86 and 110.

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