Cephalosporins

Details Cephalosporins Cephalosporins

1992-12-11

1995-10-03

Rizzo, Nicholas

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514206, 540222, 540223, C07D50124, A61K 31545

Patent

active

054552389

ABSTRACT:
A syn isomer in (R) or (S) form or a mixture thereof of a compound of the formula ##STR1## in the form of an internal salt or a non-toxic, pharmaceutically acceptable acid addition salt wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.5 are individually defined in the specification, R.sub.4 is --OH or alkoxy of 1 to 8 carbon atoms, A and A' are individually selected from the group consisting of hydrogen, an equivalent of an alkali metal or alkaline earth metal, magnesium, ammonium and an organic amine, or one or two of --COOA or --COOA' ARE --CO.sub.2 --, the wavy line means --CH.sub.2 R.sub.6 can be in the E or Z position, R.sub.6 in the quaternary ammonium form is selected from the group consisting of ##STR2## X is defined as in the specification with the proviso that when R.sub.3 is --OH or alkoxy of 1 to 8 carbon atoms, at least one R.sub.1, R.sub.2 and R.sub.5 is other than hydrogen having antibacterial properties.

REFERENCES:
patent: 4866055 (1989-09-01), Katr et al.
patent: 5075298 (1991-12-01), Aszodi et al.
patent: 5234920 (1993-08-01), Okita et al.
patent: 5373000 (1994-12-01), Machida
patent: 5373001 (1994-12-01), Aszodi et al.
patent: 5397779 (1995-03-01), Aszodi et al.

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