Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1983-03-30
1985-06-25
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544 22, A61K 31545, C07D50146
Patent
active
045254737
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or a conventional amino-protecting group, R.sup.2 is a straight or branched chain alkyl, alkenyl or alkynyl containing from 1 to 4 carbon atoms, and ##STR2## is a quaternary ammonio group as described herein, and nontoxic pharmaceutically acceptable salts, physiologically hydrolyzable esters and solvates thereof, as well as processes for their preparation, are disclosed. The compounds in which R.sup.1 is hydrogen are potent antibacterial agents.
REFERENCES:
patent: 4168309 (1979-09-01), Ayres et al.
patent: 4278671 (1981-07-01), Ochiai et al.
patent: 4278793 (1981-07-01), Durckheimer et al.
patent: 4406899 (1983-09-01), Aburaki et al.
Aburaki Shimpei
Kamachi Hajime
Naito Takayuki
Narita Yukio
Okumura Jun
Bristol-Myers Company
Ceperley Mary E.
Daus Donald G.
Lloyd Richard R.
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