Cephalosporins

Details Cephalosporins Cephalosporins

1982-06-30

1991-02-12

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514204, 540222, 540227, C07D50122, A61K 31545

Patent

active

049924311

ABSTRACT:
Novel syn isomers of 3-alkoxymethyl or 3-alkylthiomethyl-7-[2-(2-amino-4-thiazolyl)-2-oximino-acetamido]-cephalos poranic acid compounds of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl and alkynyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, acyl of an organic carboxylic acid of 1 to 18 carbon atoms and alkoxy carbonyl of 2 to 6 carbon atoms, A is selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, --NH.sub.4, magnesium, non-toxic, pharmaceutically acceptable organic amine and an easily cleavable ester group, Ra' is selected from the group consisting of alkyl of 1 to 6 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 6 carbon atoms and optionally substituted aralkyl of 7 to 12 carbon atoms, n is 0, 1 or 2, X' is selected from the group consisting of oxygen and sulfur optionally oxidized to sulfoxide or sulfone and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic activity and their preparation.

REFERENCES:
patent: 4264595 (1981-04-01), Numata et al.
patent: 4278793 (1981-07-01), Durckheimer et al.
patent: 4297352 (1981-10-01), Heyms et al.
patent: 4380541 (1983-04-01), Ochiai et al.
patent: 4399131 (1983-08-01), Durckheimer et al.
patent: 4425341 (1984-01-01), Takaya et al.
patent: 4462999 (1984-07-01), Takaya et al.

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