Cephalosporin type antibacterials having a substituted propenyl

Details Cephalosporin type antibacterials having a substituted propenyl Cephalosporin type antibacterials having a substituted propenyl

1976-11-04

1978-09-05

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

542413, 542426, 544 16, 544 22, 544 29, C07D50124, A61K 3138

Patent

active

041120876

ABSTRACT:
Compounds of the formula ##STR1## wherein R is alkyl having 1 to 4 carbon atoms, .beta.-haloethyl, allyl, propargyl, cyclopentyl or benzyl; R.sup.1 is hydrogen or an .alpha.-substituted acetamido group; R.sup.2 is hydrogen or a protecting group; and the pharmaceutically acceptable salts thereof. The 7.beta.-amino compounds are useful as intermediates for the 7.beta.-(.alpha.-substituted acetamido) compounds which are useful as antibacterials against a wide variety of gram positive and gram negative bacteria.

REFERENCES:
patent: 3769277 (1973-10-01), Long et al.
patent: 3830700 (1974-08-01), O'Callaghan et al.
patent: 3929780 (1975-12-01), Weir
patent: 3983113 (1976-09-01), Beeby
patent: 3994884 (1976-11-01), Wein
patent: 4012380 (1977-03-01), Spry
patent: 4012381 (1977-03-01), Foglio et al.
patent: 4049806 (1977-09-01), Beeby
Beeby, U.S. Patent Application, S.N. 709,696, 7-29-76.

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