Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-09-30
2000-05-16
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
540215, 544 2, C07D50104, C07D49904
Patent
active
060639172
ABSTRACT:
A process for the production of a compound of formula ##STR1## wherein R.sup.a denotes hydrogen or silyl;
R.sup.b denotes a group of formula --OR.sup.e, wherein
R.sup.e denotes hydrogen or alkyl; and
R.sup.c and R.sup.d together denote a bond;
in free form or in salt form,
which process comprises the step of spitting, in the presence of ozone, the double bond in position 3 of the ring structure of a compound of formula III ##STR2## wherein R.sub.2 and R.sub.3 are the same or different and independently of each other denote hydrogen or an organic group, and X.sup.- denotes the anion of an inorganic or organic acid and optionally silylating the amine group in position 7 of the ring system.
REFERENCES:
patent: 3351596 (1967-11-01), Chamberlin
patent: 3674784 (1972-07-01), Webber
patent: 3880851 (1975-04-01), Webber
patent: 3984401 (1976-10-01), Terao et al.
patent: 3987039 (1976-10-01), Yoshioka et al.
patent: 3991069 (1976-11-01), Barton et al.
patent: 3997528 (1976-12-01), Yoshioka et al.
patent: 4101658 (1978-07-01), Yoshioka et al.
patent: 4147863 (1979-04-01), Miyadera et al.
patent: 5856474 (1999-01-01), Ascher et al.
Fieser and Fieser, Reagents for Organic Syn., John Wiley and Sons, Inc., 1967, p. 775.
Sugawara, Tohru et al. Chemical & Pharmaceutical Bulletin, vol. 28, No. 4, Apr. 1980, pp. 1339-1341.
Peter, Heinrich et al., Helvetica Chimica Acta, vol. 57, No. 7, 1974, pp. 2044-2054.
Cephalosporins & Penicillins, Chemistry & Biology, Ed. E. H. Flynn, Academic Press N.Y. & London, 1972, p. 166.
Hashimoto, T. et al., Chem. Pharm. Bull, 26 (6), 1978, pp. 1803-11.
Bateson, J.H. et al., Chem. Let. 3, 1993, pp. 2219-24.
Fieser and Fieser, Reagents for Organic Synthesis, John Wiley and Sons, Inc., 1967, p. 775.
Ascher Gerd
Ludescher Johannes
Sturm Hubert
Wieser Josef
Biochemie Gesellschaft m.b.H.
Kalinchak Stephen G.
McNally Lydia T.
Shah Mukund J.
Sripada Pavanaram K
LandOfFree
Cephalosporin synthesis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cephalosporin synthesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cephalosporin synthesis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-259978