Cephalosporin displacement reaction

Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent

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544 27, 544 29, 544 30, C07D50136

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active

041443918

ABSTRACT:
The present invention is directed to a process for the displacement of the acetoxy group of a cephalosporanic acid by a sulfur nucleophile, in an organic solvent and under essentially anhydrous conditions.

REFERENCES:
patent: 3278531 (1966-10-01), Cox et al.
patent: 3641021 (1972-02-01), Ryan
patent: 3658799 (1972-04-01), Fardley et al.
patent: 3668203 (1972-06-01), Clark et al.
patent: 3776907 (1973-12-01), Essery et al.
Cocker et al., J. Chem. Soc., pp. 5015-5031 (1966).
Taylor, J. Chem. Soc., pp. 7020-7029 (1965).

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