Cephalosporin derivatives and their crystalline derivatives

Details Cephalosporin derivatives and their crystalline derivatives Cephalosporin derivatives and their crystalline derivatives

1987-11-16

1989-09-12

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540226, 540227, C07D50136, A61K 31545

Patent

active

048660558

ABSTRACT:
The present invention relates to novel cephalosporin derivatives and their crystalline form, processes for preparing thereof, compositions for treating and/or preventing infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof.
The present invention is based on the selection of a triazolopyrimidine ring as substituent at the 3-position of the cephem skeleton, and a 2-carboxy-4,5-dihydroxyphenylmethyloxyimino moiety as substituent at the 7-position of the cephem skeleton.
The compounds of the present invention containing these substituents have a wide antibacterial spectrum against Gram-negative bacteria including Pseudomonas aeruginosa and Gram-positive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.

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