Cephalosporin derivatives and pharmaceutical compositions in whi

Details Cephalosporin derivatives and pharmaceutical compositions in whi Cephalosporin derivatives and pharmaceutical compositions in whi

1989-10-13

1992-01-07

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540222, 540225, C07D50134, A61K 31545

Patent

active

050792415

ABSTRACT:
The present invention relates to novel cephalosporin derivatives with improved pharmacokinetics, corresponding to the formula: ##STR1## in which: R.sub.1, R.sub.2 and R.sub.3 represent a hydrogen atom, or R.sub.1 and R.sub.2 represent a hydrogen atom or a methyl group and R.sub.3 represents a carboxyl group, or ##STR2## form a cyclobutyl group and R.sub.3 represents a carboxyl group; and A and B are different and occupy the meta and para positions of the benzene ring, one representing a hydroxyl group and the other being selected from the groups ##STR3## and --NH--SO.sub.2 --Alk--NH.sub.2 in which Alk denotes a C.sub.2 -C.sub.4 lower alkylene group and also to the pharmaceutically acceptable salts and esters of the said derivatives.
It further relates to a process for the preparation of such cephalosporins and to pharmaceutical compositions in which they are present.

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