Cephalosporin derivatives, and pharmaceutical compositions conta

Details Cephalosporin derivatives, and pharmaceutical compositions conta Cephalosporin derivatives, and pharmaceutical compositions conta

1982-08-16

1985-01-29

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 26, 544 27, 544 21, 514206, C07D50124, A61K 31545

Patent

active

044965605

ABSTRACT:
New cephalosporin derivatives, of the formula: ##STR1## in which R.sub.1 is a heterocyclic, phenyl, p-hydroxyphenyl, phenoxy or dichlorophenylthio radical and R.sub.2 is a hydrogen atom, or R.sub.1 is phenyl or p-hydroxyphenyl and R.sub.2 is an amino radical, R.sub.3 is hydrogen, phenyl, substituted phenyl, alkylthio or substituted amino or a radical of the structure --A--R'.sub.3, which A is --CH.sub.2 --, --NH-- or --NHCO-- and R'.sub.3 is a substituted pyridinio radical, R is a carboxyl radical or a carboxylato radical if R.sub.3 is a --AR'.sub.3 radical and X is a sulphur or oxygen atom, the said alkyl moieties or radicals containing 1 to 4 carbon atoms each in their D, L and D,L forms, where these exist, and their salts are narrow-spectrum anti-bacterial agents which are active against gram-positive bacteria.

REFERENCES:
patent: 3962223 (1976-06-01), Martel et al.
patent: 4060687 (1977-11-01), Christensen et al.
patent: 4182866 (1980-01-01), Miki et al.

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