Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-02-11
1993-08-03
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514201, 540221, 540222, 540225, C07D50136, A61K 31545
Patent
active
052329186
ABSTRACT:
Cephalosporin derivatives having a 3-position substituent of formula I are described: ##STR1## wherein R.sup.1 is hydrogen, alkenyl or optionally substituted alkyl, Het is a 5- or 6-membered heterocyclic ring bonded via a carbon atom to the amide linkage, wherein Het is selected from a group of the formulae II-III: ##STR2## wherein A is CH or a nitrogen atom; B is oxygen, sulphur or a group NR.sup.4 ; one or two of D, E, F and G are nitrogen atoms and the remainder are CH groups: or Het is a pyrazinone, pyridinone, pyridazinone or pyrimidinone ring, or is a thione equivalent of such a ring, said rings having a substituent R.sup.4 on one nitrogen atom, or is pyranone, or pyranthione; the ring Het being fused by any two adjacent carbon atoms to the benzene ring; and Het being attached to the --CH.sub.2 NR.sup.1 CO-- group via a carbon atom;
REFERENCES:
patent: 5008259 (1991-04-01), Siret et al.
patent: 5019570 (1991-05-01), Arnould et al.
patent: 5055462 (1991-10-01), Daves et al.
Arnould Jean C.
Boucherot Dominique
Davies David H.
Jung Frederick H.
Strawson Colin J.
ICI Pharma
Imperial Chemical Industries plc
Rizzo Nicholas S.
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