Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-12-28
1989-12-19
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540227, 540222, 540226, C07D50136, A61K 31545
Patent
active
048883328
ABSTRACT:
The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof.
The novel cephalosporin derivatives according to the present invention contain condensed heterocyclic groups, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring as substituents at the 3-position of the cephem skeleton, and a hydroxyimino, an alkyloxyimino or an acyloxyimino moiety as substituents at the 7-position of the cephem skeleton.
The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against gram-negative bacteria and also against gram-positive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.
REFERENCES:
patent: 4103085 (1978-07-01), Naito et al.
patent: 4104469 (1978-08-01), Naito et al.
patent: 4151352 (1979-04-01), Naito et al.
patent: 4278793 (1981-07-01), Durckheimer et al.
patent: 4316024 (1982-02-01), Iimura et al.
patent: 4331666 (1982-05-01), Nannini et al.
patent: 4436912 (1984-03-01), Wheeler
patent: 4500526 (1985-02-01), Imae et al.
patent: 4526977 (1985-07-01), Commons et al.
patent: 4547494 (1985-10-01), Oine et al.
patent: 4576956 (1986-03-01), Makisumi
patent: 4587333 (1986-05-01), Ono et al.
patent: 4594417 (1986-06-01), Yang
patent: 4600773 (1986-07-01), Engle
patent: 4604457 (1986-08-01), Torii et al.
patent: 4609654 (1986-09-01), Labeeuw et al.
patent: 4621081 (1986-04-01), O'Callaghan et al.
Dunn, J. Antimicrob. Chemotherapy (1982) 10, Suppl. C, pp. 1-10.
Natio, et al., Chem. Abstracts vol. 88 (1978), entry 22797.
Chemical Abstracts 102:113169e (1989).
Chemical Abstracts vol. 102, 1985 Abstract No. 24539Z.
Chemical Abstracts vol. 100, 1984 Abstract No. 22505d.
Chemical Abstracts vol. 102, 1985 Abstract No. 6056u.
Chemical abstracts vol. 103, 1985 Abstract No. 37281p.
Alpegiani et al., "Cephalosporins VI", The Journal of Antibiotics, vol. XXXVI, No. 8, Aug. 1983, pp. 1013-1019.
Kosuzume Hiroshi
Mizota Masahiro
Mochida Ei
Ohnishi Haruo
Suzuki Yasuo
Mochida Pharmaceutical Co. Ltd.
Rizzo Nicholas S.
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